4 POSITIONS OPEN for PRE-DOCTORAL TRAINING at the STRUCTURAL BIOLOGY UNIT of IBMB-CSIC

PRESENTATION

The Structural Biology Unit (SBU) of the Molecular Biology Institute of Barcelona (IBMB) is one of leading research units of the Spanish Research Council (CSIC). The SBU consists of seven research groups, featuring over 60 researchers, which aim to understand the cell machinery from a structural perspective. In this realm, the unit stands a leading position in the field of macromolecular X-ray crystallography in Spain.

In 2015, the SBU was selected as a “María de Maeztu” Unit of Excellence by the Spanish Ministry of Economy and Competitiveness (MINECO), which recognizes exceptional quality in terms of research, training, human resources, outreach and technology transfer.

Next 2018 FPI fellowship call from MINECO will include four positions to do the PhD at two SBU research groups:

  • Protein & Nucleic Acid Complexes and Molecular Machines
  • Virus and Large Biological Complexes

 

FPI FELLOWSHIP CALL 2018     

The four fellowships are to join one of the following research lines:

 

Protein & Nucleic Acid Complexes and Molecular Machines

1.     “Structural Biology of protein-DNA transcription complexes”

Applications are invited for a predoctoral position within Prof. Miquel Coll’s laboratory at the Molecular Biology Institute of Barcelona (IBMB-CSIC) to work on the Project “Structural Biology of protein-DNA transcription complexes”. Our laboratory is interested in determining, by X-ray diffraction and cryo-electron microscopy,  the structure of several protein-DNA complexes with putative therapeutic interest. The position is supported by a FPI fellowship linked to a project grant awarded by the Spanish Ministry of Science, Innovation and Universities.

2.     “Structural Biology of protein-DNA transcription complexes”

Applications are invited for a predoctoral position within Prof. Miquel Coll’s laboratory at the Molecular Biology Institute of Barcelona (IBMB-CSIC) to work on the Project “Structural Biology of protein-DNA transcription complexes”. Our laboratory is interested in determining, by X-ray diffraction and cryo-electron microscopy,  the structure of several protein-DNA complexes with putative therapeutic interest. The position is supported by a FPI fellowship linked to a Maria de Maeztu award of excellence granted to the the Structural Biology Unit of the IBMB-CSIC.

 

Virus and Large Biological Complexes

3.     “Structural bases of viral infection: replication machineries of RNA viruses”

Most emerging and re-emerging human and animal viral diseases are associated with RNA viruses. One way to limit the impact of these pathogens is to prevent their replication and a thorough understanding of their replication and transcription machineries is therefore essential. The goal of this project is the structural and functional characterization of the L protein from Ebola virus, a representative member of the Filoviridae family of non-segmented (-)ssRNA viruses. We will use a number of molecular and structural biology techniques. In particular, X-ray crystallography and combinations of X-ray crystallography and Cryo-electron microscopy.

4.     “Structural Biology of proteins involved in pathological processes”

This research line pursues the understanding of the cell machinery in physiological and pathological processes from a structural perspective. We use a number of molecular and structural biology techniques. In particular, combinations of X-ray crystallography and Cryo-electron microscopy. The goal of the present project is the characterization of Vault particles from different organisms. The vault particle is the largest ribonucleoprotein particle described in the eukaryotic kingdom. Regarding the hypothetical functions of vaults, it has proposed to be implicated in a diversity of cellular processes, including multidrug resistance, transport mechanisms and cell signaling but they are all pending confirmation. Solving the structure of these particles would  allow us to decipher the evolutionary relationships linking this particle from ancient microorganisms to higher eukaryotes, also providing essential information about its function.

 

The grant salary for 4-years will be specified in the MINECO call. (You can consult 2017 Call, gross salary per year 422€).

 

ELIGIBILITY CRITERIA

Candidates should have a university degree and a master’s degree by September 2018, with a minimum of 300 European Higher Education Area ECTS credits (at least 60 must come from the master’s studies).  In addition, candidates must have a good level of English.

 

HOW TO APPLY?

The application will be done online at the MICINN website once call is published

We encourage you to contact us before application providing:

      • Personal data and CV specifying education and experience.
      • Covering letter, including motivation for applying and indicating the research line of interest.
      • 2 reference contacts.

If you need additional information, please contact:

Laia Vives Adrián

SBU Maria de Maeztu Project Manager

lvacri@ibmb.csic.es

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